Assistant Dean (Research)
Institute of Health and Biomedical Innovation (IHBI)
Professor Greig de Zubicaray is Assistant Dean (Research) and Deputy Director of the Institute of Health and Biomedical Innovation (IHBI).
In addition to his administrative duties he is a clinical neuropsychologist and cognitive neuroscientist, and leads a research program. concerned with understanding brain mechanisms involved in language, memory and their disorders (following brain tumours and stroke), neuroimaging methodologies, the ageing brain and cognitive decline, and imaging genetics.
Work in his lab makes use of a range of methodologies, including functional magnetic resonance imaging (fMRI), electrophysiology, transcranial direct current stimulation (tDCS), and behavioural paradigms, in both healthy and neurologically disordered populations.
Among his most highly cited work is a longitudinal structural MR study of the progressive loss of grey matter volume in Alzheimer’s disease, as well as work focussing on the loss of hippocampal volume, linked to decline in episodic memory in Alzheimer’s disease, as well as ventricular dilation, which is a non-specific marker of the composite atrophy of white matter and grey matter.
Professor de Zubicary has also contributed to a twin study using the technique of MR diffusion tensor imaging (DTI) to investigating the contribution of genetics to white matter connectivity in relation to general intelligence. He has also been involved in psychopharmacological studies investigating the effects of challenge with the catecholamine precursor levodopa on the functional connectivity of cerebral cortex in healthy young adults.
Figure: Cortical regions with increased activity Brain activity to perfusion-weighted MRI imaging in association with spoken word production. The task is action picture naming in healthy adults; activations are revealed as a hot metal scale projected upon the cortical surface, revealing a distributed and bilateral network extending far beyond the classical productive speech region, i.e. Broca’s area